ISO Anime from childhood!

Hey guys, so it’s been burning inside me for years and I’m finally trying to figure it out. I’ve been looking for a particular anime I watched a long long time ago and was wondering if y’all could help me out? What I remember is the protagonist is a female who carries a massive sword and she also has a chunk of crystal that is a piece of her brothers heart. Her brother had exploded/shattered and that’s the only piece left of him. I wish I could remember more but that’s all I got. Anyone know what anime this might be?



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